Non-neoplastic histiocytic and dendritic cell disorders in lymph nodes

Macrophage/histiocytic antigen CD68 expression in neoplastic and reactive lymph nodes.

There are some reports, suggesting that infiltrating macrophages may promote tumour progression in non-Hodgkin's lymphoma (nHL). The aim of the study was an evaluation of macrophages, marked by antibody against CD68 in indolent and aggressive nHL. The study was performed in 65 patients: 50 with nHL and 15 with lymph nodes affected by reactive hyperplasia. Immunohistochemical analyses were perfo...

Dendritic cell migration to peripheral lymph nodes.

Dendritic cells are potent antigen-presenting cells endowed with the unique ability to prime T-cell responses. To present foreign antigens to na ive T cells, dendritic cells must migrate from inflamed or injured peripheral tissues to the closest draining lymph nodes through afferent lymphatic vessels. In addition, conventional dendritic cells, plasmacytoid dendritic cells and monocytes enter ly...

The Dendritic Cell Populations of Mouse Lymph Nodes 1

The dendritic cell populations of mouse lymph nodes.

The dendritic cells (DC) of mouse lymph nodes (LN) were isolated, analyzed for surface markers, and compared with those of spleen. Low to moderate staining of LN DC for CD4 and low staining for CD8 was shown to be attributable to pickup of these markers from T cells. Excluding this artifact, five LN DC subsets could be delineated. They included the three populations found in spleen (CD4(+)8(-)D...

Uncommon histiocytic disorders: the non-Langerhans cell histiocytoses.

BACKGROUND Histiocytic disorders are currently identified by their component cells. The non-Langerhans Cell Histiocytoses (non-LCH) are a group of disorders defined by the accumulation of histiocytes that do not meet the phenotypic criteria for the diagnosis of Langerhans cells (LCs). The non-LCH consist of a long list of diverse disorders which have been difficult to categorize. A conceptual w...